Modified thoracoscopic pleural cryo-biopsy in diagnosis of exudative pleural effusion of undetermined etiology

Abstract Background Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion, but sometimes it difficult to obtain sufficient biopsies using conventional forceps. This study evaluated efficacy, safety, and diagnostic value of a modified technique cryoprobe during thoracoscopy. Results single-center prospective in patients that underwent rigid forceps followed by at same setting after injection subpleural mixture adrenaline xylocaine. Biopsies were reviewed an independent pathologist; any complications recorded, all followed-up post-procedure. Twenty-four (12 males; mean age was 56 ± 15.1years) included. The yield both biopsy (RFB) (CPB) 100%. CPB had more surface area than RFB with no difference regarding largest diameter ( p = 0.064). similar results presence fat cells. much less crushed cells better tissue preservation 0.004). No significant reported. Conclusions highly effective safe way obtaining besides affording good quality size especially thick firmly adherent pleura.